(1.) Shosanna Dreyfus (Inglourious Basterds) - She watched her parents get murdered and almost got killed herself when a group of nazis shoot through the floorboards at her and her family. Her whole part is based on a vengeful character who succeeds on her plot to burn down her theatre with the most important nazis including, Hitler, Gerbels, and Bowman.
(2.) Cortana (Halo) - She puts up with drastic actions took by master chief, she won't die, and she's the most ridiculous AI ever.
(3.) Sheva (Resident Evil) - She is just amazing. Enough said.
(4.) Quorra (Tron Legacy) - Played by Olivia Wilde and is amazing and kills everything.
(5.) Thalia Grace (Percy Jackson) - She is a daughter of Zeus and is a female huntress for Artemis. So she is just awesome.